Reducing the risk of cognitive decline
What the 2024 Lancet Commission and WHO say about the modifiable factors that can lower dementia risk across life - and practical actions.
We cannot control every cause of dementia, but a large body of research says that addressing certain factors across life could prevent or delay a meaningful share of cases. The 2024 Lancet Commission estimates that around 45% of dementia cases could in principle be prevented or delayed by tackling 14 modifiable risk factors [Livingston G 2024] .
This is about lowering risk, not a guarantee - and it is never too early or too late to act [Livingston G 2024] .
The 14 factors
The Commission lists: lower education, hearing loss, high blood pressure, smoking, obesity, depression, physical inactivity, diabetes, excessive alcohol, traumatic brain injury, air pollution, social isolation, and - newly added in 2024 - untreated vision loss and high LDL cholesterol [Livingston G 2024] .
Practical actions
You do not need to fix everything. Pick what is realistic:
- Move regularly. Aim toward 150 minutes of moderate activity a week if you can [World Health Organization 2019] .
- Protect your hearing and vision - get tested, use hearing aids and glasses if needed.
- Look after your heart numbers - blood pressure, cholesterol, blood sugar.
- Stay socially connected and treat low mood; isolation and depression both matter.
- Don’t smoke; keep alcohol low.
- Keep learning and stay mentally active.
Focus on what you can change
Not everything is in our control, but several habits meaningfully shift the odds:
- Stay physically active most days.
- Keep blood pressure, cholesterol, and blood sugar in check.
- Don’t smoke, and keep alcohol within limits.
- Address hearing loss and stay socially connected.
Feed the brain
- Favour a vegetable-rich, whole-food eating pattern.
- Include beans, nuts, fish, and healthy fats.
- Limit ultra-processed foods and added sugar.
Keep the mind and body engaged
- Keep learning new things.
- Stay in regular contact with others.
- Protect your sleep.
- Manage stress with calming routines.
Start small
You don’t need to change everything at once. Choose one habit from each area and build gradually - consistency matters more than intensity.
A balanced note
WHO rates the strength of evidence as varying by factor - strongest for physical activity and managing cardiovascular risk, with others more uncertain [World Health Organization 2019] . The encouraging message is that healthy habits help your whole body and brain, with little downside.
Turn this into action with Practice.
References
- 1. Livingston G, Huntley J, Liu KY, et al. (2024). Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. The Lancet. doi:10.1016/S0140-6736(24)01296-0
- 2. World Health Organization (2019). Risk reduction of cognitive decline and dementia: WHO guidelines. World Health Organization, Geneva. Link